Dibutylamine → N,N-dibutyl 1-phenyl isoquinoline 3-carboxamide

HRID 615407노트

반응식

HRID 615407 반응식
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([C:17](O)=[O:18])[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.ClC(OCC)=O.[CH2:33]([NH:37][CH2:38][CH2:39][CH2:40][CH3:41])[CH2:34][CH2:35][CH3:36]>C1(C)C=CC=CC=1>[CH2:33]([N:37]([CH2:38][CH2:39][CH2:40][CH3:41])[C:17]([C:9]1[N:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:16]2[C:11]([CH:10]=1)=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:18])[CH2:34][CH2:35][CH3:36]

참가 물질

6

반응물 4

HCID 8148DibutylamineHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 4078961-Phenylisoquinoline-3-carboxylic acid

생성물 1

HCID 20427637N,N-dibutyl 1-phenyl isoquinoline 3-carboxamide수율 41.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Operations are carried out as for Example 7, starting from 2.5 g of 1-phenyl isoquinoline 3-carboxylic acid, 1.15 g of triethylamine, 1.24 g of ethyl chloroformate and 1.66 g of dibutylamine in 100 ml of toluene. After chromatography and recrystallization in petroleum ether, 1.5 g of N,N-dibutyl 1-phenyl isoquinoline 3-carboxamide melting at 62° C. is obtained.

후처리

  1. customAfter chromatography and recrystallization in petroleum ether

출처 및 근거

ORD 기록
ord-f1d271207d2244c4886c1a155473a2b5
출처 데이터셋
uspto-grants-1985_02
특허 번호
US04499094

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