Trifluoroacetic acid → (2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenyl)pyrrolidine-2-carboxamide

HRID 61543Notes

Reaction equation

HRID 61543 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[C:6]([NH:8][C:9]1[CH:10]=[C:11]([C:15]2[N:24]=[C:23]([NH:25][C:26]3[CH:27]=[C:28]4[C:32](=[CH:33][CH:34]=3)[N:31](C(OC(C)(C)C)=O)[N:30]=[CH:29]4)[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=2)[CH:12]=[CH:13][CH:14]=1)=[O:7].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:31]1[C:32]2[C:28](=[CH:27][C:26]([NH:25][C:23]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16]=[C:15]([C:11]4[CH:10]=[C:9]([NH:8][C:6]([C@H:2]5[CH2:3][CH2:4][CH2:5][NH:1]5)=[O:7])[CH:14]=[CH:13][CH:12]=4)[N:24]=3)=[CH:34][CH:33]=2)[CH:29]=[N:30]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59361907tert-butyl 5-(2-(3-((R)-pyrrolidine-2-carboxamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Product 1

HCID 59361842(2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenyl)pyrrolidine-2-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl 5-(2-(3-((R)-pyrrolidine-2-carboxamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate (65 mg, 0.12 mmol) was added a solution of 1:1 TFA:CH2Cl2 (2 mL) and stirred at RT for 2 h. The reaction mixture was concentrated in vacuo and the residue was triturated with ethyl ether to get a yellow solid. Product was purified using prep HPLC (method 25-50_70 mins) to afford (2R)—N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenyl)pyrrolidine-2-carboxamide. (64 mg, 100%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue was triturated with ethyl ether
  3. customto get a yellow solid
  4. customProduct was purified
  5. customprep HPLC (method 25-50_70 mins)

Sources & evidence

ORD record
ord-24ed513afe614101b39b1df0bf0b5e27
Source dataset
uspto-grants-2016_09
Patent number
US09440961B2

Reaction notes

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