反应详情

A suspension of 2-aminobenzimidazole (10.0 g) and the sodium salt of N-cyano-N'-phenyl thiourea (7.5 g) was stirred at room temperature for 30 minutes. Mercuric chloride (10.2 g) was added and stirring continued for 16 h. The mixture was filtered and the filtrate evaporated to a gum. A solution of the gum in methanol soon yielded a solid (3.25 g). The solid was collected, suspended in tetrahydrofuran and hydrogen sulphide added until no further black precipitate formed. The mixture was filtered and the filtrate evaporated to give a yellow solid which showed several components on thin layer chromatography. The components were separated on a column of silica gel to give the sub-title compound as white crystals (1.22 g) mp, 271°-3°.

1. filtrationThe mixture was filtered
2. customthe filtrate evaporated to a gum