反应详情

A solution of 5 g of 3-acetylbenzoic acid in dry MeOH was saturated with hydrogen chloride gas. The reaction vessel was stoppered and kept at room temperature for 2 days. The MeOH was evaporated and the residue extracted into diethylether and clarified by filtration. The ether was evaporated and the dark oil was chromatographed through a short column of silica gel eluting with methylene chloride. The combined fractions were evaporated to dryness giving 4.25 g of a yellow oil that solidified on standing. The solid ester was used as obtained.

1. customThe MeOH was evaporated
2. extractionthe residue extracted into diethylether
3. filtrationclarified by filtration
4. customThe ether was evaporated
5. customthe dark oil was chromatographed through a short column of silica gel eluting with methylene chloride
6. customThe combined fractions were evaporated to dryness