反应详情

A solution of 1 g (6 mmoles) of the ester from step a. dissolved in 10 ml of dry CH2Cl2 and cooled in an ice bath was treated dropwise with 0.96 g (6 mmoles) of Br2 in 2 ml CH2Cl2. The reaction flask was sealed and stored at -15° overnight. Gentle swirling of the reaction solution induced crystallization of fine white needles that were collected by filtration and washed with cold CH2Cl2 /hexanes.

1. temperaturecooled in an ice bath
2. customThe reaction flask was sealed
3. customcrystallization of fine white needles that
4. filtrationwere collected by filtration
5. washwashed with cold CH2Cl2 /hexanes