HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → Methyl 2-bromo-5-hydroxy-4-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Methyl 3-hydroxy-4-methylbenzoate | HCID 354091 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-bromo-5-hydroxy-4-methylbenzoate | HCID 20428674 | — |
Reaction Steps
A solution of 1 g (6 mmoles) of the ester from step a. dissolved in 10 ml of dry CH2Cl2 and cooled in an ice bath was treated dropwise with 0.96 g (6 mmoles) of Br2 in 2 ml CH2Cl2. The reaction flask was sealed and stored at -15° overnight. Gentle swirling of the reaction solution induced crystallization of fine white needles that were collected by filtration and washed with cold CH2Cl2 /hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04499299 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-927cd99e7e33408fa0b3081985cc9c13 |
| Source note | uspto-grants-1985_02 |