Isopropylamine → HCID 14855258, compound

HRID 615632Notes

Reaction equation

HRID 615632 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.Br[CH2:11][CH2:12]Br.[Na].[OH-].[K+].BrCCC1C(C)=CSC=1OC1SC=C(C)C=1CCBr.[CH:36]([NH2:39])([CH3:38])[CH3:37]>>[CH3:37][CH:36]([NH:39][CH2:11][CH2:12][O:9][C:6]1[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[CH:4][CH:5]=1)[CH3:38]

Participants

7

Reactant 6

HCID 6363IsopropylamineHCID 78391,2-DibromoethaneHCID 140864-(Methylthio)phenolHCID 14797Potassium HydroxideHCID 5360545SodiumHCID 70473109HCID 70473109, compound

Product 1

HCID 14855258HCID 14855258, compound

Procedure

4-(Methylthio)phenol is reacted with a large excess of 1,2-dibromethane in the presence of an alkali metal base such as sodium or potassium hydroxide. The product of that reaction, 2-bromoethyl-4-methylthiophenyl ether, is then reacted with isopropylamine as in Preparation 1 to give the title compound.

Sources & evidence

ORD record
ord-eb548af5d0e44b7fa2567c7ca18c45b5
Source dataset
uspto-grants-1985_02
Patent number
US04500529

Reaction notes

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