HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl acetamidocyanoacetate → Ethyl 2-cyano-2-acetamido-2-(2,3-dihydro-1H-inden-2yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl acetamidocyanoacetate | HCID 95422 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 2-bromo-2,3-dihydro-1H-indene | HCID 10965463 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ethyl 2-cyano-2-acetamido-2-(2,3-dihydro-1H-inden-2yl)acetate | HCID 13517005 | — |
Reaction Steps
Sodium ethoxide (40 gms) was stirred in 1 L of dimethyl sulfoxide until solution was complete. Then, 100 g of ethyl acetamido-cyanoacetate was added, and again stirred until solution was complete. 2-Bromoindane (101 g) was slowly added, using a few ml of DMSO to wash the container and addition funnel. The solution was stirred over a weekend.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04500713 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-9fb38fe8ea064d439ab89cb9e2234f71 |
| Source note | uspto-grants-1985_02 |