反应详情

Into 50 ml of acetone, were added 12.5 g of 2-amino-4-phenylthiazole and 7.0 g of triethylamine. The mixture was cooled to -10°--20° C. To the mixture solution, 11.7 g of α-chloropropionylchloride was slowly dropped. After the completion of the dropwise addition, the resultant mixture solution was agitated at room temperature for 3 hours. Then, the reaction mixture was poured into 500 ml of water. Resulting oily substance was extracted with ethyl acetate. The extract was then successively washed with dilute hydrochloric acid and water. After drying the solution, the ethyl acetate was removed under reduced pressure. The residue was recrystallized from an ether/n-hexane mixed solvent to obtain 13.2 g of 2-(α-chloropropionylamino)-4-phenylthiazole.

1. temperatureThe mixture was cooled to -10°--20° C
2. additionAfter the completion of the dropwise addition
3. extractionResulting oily substance was extracted with ethyl acetate
4. washThe extract was then successively washed with dilute hydrochloric acid and water
5. customAfter drying the solution
6. customthe ethyl acetate was removed under reduced pressure
7. customThe residue was recrystallized from an ether/n-hexane mixed solvent