Dicyclohexylcarbodiimide → N-[(3-pyridyl)methyl]-N-cyclohexyl-alpha-(n-butylthio)acetamide

HRID 615871Notes

Reaction equation

HRID 615871 reaction equation
[CH:1]1([NH:7][CH2:8][C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:15]([S:19][CH2:20][C:21](O)=[O:22])[CH2:16][CH2:17][CH3:18].C1(N=C=NC2CCCCC2)CCCCC1>C1(C)C=CC=CC=1>[N:11]1[CH:12]=[CH:13][CH:14]=[C:9]([CH2:8][N:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:21](=[O:22])[CH2:20][S:19][CH2:15][CH2:16][CH2:17][CH3:18])[CH:10]=1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 88607(Butylthio)acetic acidHCID 757273N-(pyridin-3-ylmethyl)cyclohexanamine

Product 1

HCID 13652431N-[(3-pyridyl)methyl]-N-cyclohexyl-alpha-(n-butylthio)acetamide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

N-[(3-pyridyl)methyl]-N-cyclohexyl-α-(n-butylthio)acetamide was prepared by the method of Example 2 by reacting 9.5 g. of N-cyclohexyl-[(3-pyridyl)methyl]amine with 7.4 g. of α-(n-butylthio)acetic acid and 9.0 g. of N,N'-dicyclohexylcarbodiimide in 150 ml of toluene. Weight 3.5 g. as an oil.

Sources & evidence

ORD record
ord-a3b3d36ee45348c6a1c737e25c9656d8
Source dataset
uspto-grants-1985_02
Patent number
US04501746

Reaction notes

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