Dicyclohexylcarbodiimide → N-[1-(3-pyridyl)ethyl]-N-cyclohexyl-alpha-(n-butylthio)acetamide

HRID 615872Notes

Reaction equation

HRID 615872 reaction equation
[CH:1]1([NH:7][CH:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH3:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:16]([S:20][CH2:21][C:22](O)=[O:23])[CH2:17][CH2:18][CH3:19].C1(N=C=NC2CCCCC2)CCCCC1>ClCCl>[N:12]1[CH:13]=[CH:14][CH:15]=[C:10]([CH:8]([N:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:22](=[O:23])[CH2:21][S:20][CH2:16][CH2:17][CH2:18][CH3:19])[CH3:9])[CH:11]=1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 88607(Butylthio)acetic acidHCID 20406780N-cyclohexyl-[1-(3-pyridyl)ethyl]amine

Product 1

HCID 20406784N-[1-(3-pyridyl)ethyl]-N-cyclohexyl-alpha-(n-butylthio)acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-[1-(3-pyridyl)ethyl]-N-cyclohexyl-α-(n-butylthio)acetamide was prepared by the method of Example 2 by reacting 5.0 g. of N-cyclohexyl-[1-(3-pyridyl)ethyl]amine with 3.6 g. of α-(n-butylthio)acetic acid and 5.0 g. of N,N'-dicyclohexylcarbodiimide in 200 ml. of dichloromethane. Oil.

Sources & evidence

ORD record
ord-eb5066fbc0a64bc08691906e4fbb2049
Source dataset
uspto-grants-1985_02
Patent number
US04501746

Reaction notes

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