Dicyclohexylcarbodiimide → N-[(3-pyridyl)methyl]-N-(1,1-dimethylethyl)-alpha-(n-butylthio)acetamide

HRID 615875Notes

Reaction equation

HRID 615875 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])[CH:2]=1.[CH2:13]([S:17][CH2:18][C:19](O)=[O:20])[CH2:14][CH2:15][CH3:16].C1(N=C=NC2CCCCC2)CCCCC1>ClCCl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][N:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:19](=[O:20])[CH2:18][S:17][CH2:13][CH2:14][CH2:15][CH3:16])[CH:2]=1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 88607(Butylthio)acetic acidHCID 9615282-methyl-N-(pyridin-3-ylmethyl)propan-2-amine

Product 1

HCID 13652436N-[(3-pyridyl)methyl]-N-(1,1-dimethylethyl)-alpha-(n-butylthio)acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-[(3-pyridyl)methyl]-N-(1,1-dimethylethyl)-α-(n-butylthio)acetamide was prepared by the method of Example 2 by reacting 8.2 g. of N-[(3-pyridyl)methyl]-(1,1-dimethylethyl)amine with 7.4 g. of α-(n-butylthio)acetic acid and 10.3 g. of N,N'-dicyclohexylcarbodiimide in 150 ml. of dichloromethane. Weight 1.6 g. M.P. 55°-56° C.

Sources & evidence

ORD record
ord-262f376f04704635ae9d1e3c202a97b5
Source dataset
uspto-grants-1985_02
Patent number
US04501746

Reaction notes

Loading…