2-Bromo-N,N,2-trimethylpropanamide → N,N,beta,4-tetramethyl-3-phenylpyrazole-1-propionamide

HRID 615981Notes

Reaction equation

HRID 615981 reaction equation
Br[C:2]([CH3:9])(C)[C:3]([N:5]([CH3:7])[CH3:6])=[O:4].[CH3:10][C:11]1[C:12]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:13][NH:14][CH:15]=1.[C:22]1(C2C=CNN=2)C=CC=CC=1>>[CH2:9]([CH:2]([N:14]1[CH:15]=[C:11]([CH3:10])[C:12]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[N:13]1)[C:3]([N:5]([CH3:7])[CH3:6])=[O:4])[CH3:22].[CH3:6][N:5]([CH3:7])[C:3](=[O:4])[CH2:2][CH:9]([CH3:22])[N:14]1[CH:15]=[C:11]([CH3:10])[C:12]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[N:13]1

Participants

5

Reactant 3

HCID 124756442-Bromo-N,N,2-trimethylpropanamideHCID 178420101HCID 178420101, compoundHCID 178430907HCID 178430907, compound

Product 2

HCID 20370400N,N,beta,4-tetramethyl-3-phenylpyrazole-1-propionamideHCID 20568045alpha-ethyl-N,N,4-trimethyl-3-phenylpyrazole-1-acetamide

Procedure

Following the procedure of Example 121, but substituting 2-bromo-N,N-dimethylbutyramide for 2-bromo-N,N,2-trimethylpropionamide, and 4-methyl-3-phenylpyrazole for 3-phenylpyrazole, there were obtained the already described α-ethyl-N,N,4-trimethyl-3-phenylpyrazole-1-acetamide and N,N,β,4-tetramethyl-3-phenylpyrazole-1-propionamide having a boiling point of 170°/0.2 mm.

Sources & evidence

ORD record
ord-2349013dd8084e758478cf9cb2b197d1
Source dataset
uspto-grants-1978_02
Patent number
US04072498

Reaction notes

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