Benzene → HCID 12962300, compound

HRID 616017Notes

Reaction equation

HRID 616017 reaction equation
[CH2:1]([CH:3]1[NH:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:4]1)[CH3:2].C1C=CC=CC=1.[Cl:20][CH:21]([Cl:25])[C:22](Cl)=[O:23]>C(N(CC)CC)C>[CH2:1]([CH:3]1[N:7]([C:22](=[O:23])[CH:21]([Cl:25])[Cl:20])[CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6593Dichloroacetyl chlorideHCID 20221973HCID 20221973, compound

Product 1

HCID 12962300HCID 12962300, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Twenty-one and three tenths ml. of a solution containing 5.3 g of 2-ethyl-5-phenyl oxazolidine was diluted with 25 ml. of benzene and 3.1 g. of triethylamine was added. The mixture was cooled in a room temperature water bath and 4.4 g. of dichloroacetyl chloride was added dropwise with stirring. The stirring was continued for about 30 minutes after addition was complete. The solution was washed with water, separated, dried over magnesium sulfate and removed under vacuum. There was obtained a yield of 8.7 g. of the title compound, an oil, ND30 = 1.5600.

Workup

  1. additionwas diluted with 25 ml
  2. additionafter addition
  3. washThe solution was washed with water
  4. customseparated
  5. dry with materialdried over magnesium sulfate
  6. customremoved under vacuum
  7. customThere was obtained a yield of 8.7 g

Sources & evidence

ORD record
ord-2489221b97404d42a449594c020a7b55
Source dataset
uspto-grants-1978_02
Patent number
US04072688

Reaction notes

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