Acetone → HCID 12962350, compound

HRID 616020Notes

Reaction equation

HRID 616020 reaction equation
[C:1]1([CH:7]2[NH:11][CH2:10][CH2:9][S:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CC(C)=O.C(N(CC)CC)C.[Cl:23][CH:24]([Cl:28])[C:25](Cl)=[O:26]>O>[C:1]1([CH:7]2[N:11]([C:25](=[O:26])[CH:24]([Cl:28])[Cl:23])[CH2:10][CH2:9][S:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 180AcetoneHCID 6593Dichloroacetyl chlorideHCID 8471TriethylamineHCID 207062-phenyl-thiazolidine

Product 1

HCID 12962350HCID 12962350, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Five grams of 2-phenyl thiazolidine was dissolved in 50 ml. of acetone, 3.1 g. of triethylamine was added and the mixture stirred in a room temperature water bath, while 4.4 g. of dichloroacetyl chloride was added dropwise. The mixture was allowed to stand for about 30 minutes and then poured into water, extracted with methylene chloride, separated, dried over magnesium sulfate, and the solvent stripped under vacuum. There was obtained a yield of 7.3 g. of an oil, the title compound, ND30 32 1.5836.

Workup

  1. extractionextracted with methylene chloride
  2. customseparated
  3. dry with materialdried over magnesium sulfate
  4. customThere was obtained a yield of 7.3 g

Sources & evidence

ORD record
ord-ce084045556940edb8db259006df819e
Source dataset
uspto-grants-1978_02
Patent number
US04072688

Reaction notes

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