Benzene → HCID 12962355, compound

HRID 616021Notes

Reaction equation

HRID 616021 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[NH:12][CH2:11][CH2:10][S:9]2)[CH:5]=[CH:6][CH:7]=1.C1C=CC=CC=1.[Cl:19][CH:20]([Cl:24])[C:21](Cl)=[O:22]>C(N(CC)CC)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[N:12]([C:21](=[O:22])[CH:20]([Cl:24])[Cl:19])[CH2:11][CH2:10][S:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 241BenzeneHCID 6593Dichloroacetyl chlorideHCID 108528THIAZOLIDINE, 2-(M-CHLOROPHENYL)

Product 1

HCID 12962355HCID 12962355, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Five grams of 2-m-chlorophenyl thiazolidine was dissolved in 50 ml. of benzene and 2.6 g. of triethylamine and the mixture was stirred in a room temperature water bath, while 3.7 g. of dichloroacetyl chloride was added dropwise. After standing for about 30 minutes, the mixture was washed with water, separated and dried over magnesium sulfate and the benzene stripped under vacuum. There was obtained a yield of 7.2 g. of an oil, the title compound, ND30 = 1.5805.

Workup

  1. washthe mixture was washed with water
  2. customseparated
  3. dry with materialdried over magnesium sulfate
  4. customThere was obtained a yield of 7.2 g

Sources & evidence

ORD record
ord-37aabd9c88d1437e8dea2df3413bbc92
Source dataset
uspto-grants-1978_02
Patent number
US04072688

Reaction notes

Loading…