Benzene → HCID 13363481, compound

HRID 616022Notes

Reaction equation

HRID 616022 reaction equation
C1C=CC=CC=1.[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[C:9]=1[CH:15]1[NH:19][CH2:18][CH2:17][S:16]1.[Cl:20][CH2:21][C:22](Cl)=[O:23]>C(N(CC)CC)C>[Cl:14][C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([Cl:7])[C:9]=1[CH:15]1[N:19]([C:22](=[O:23])[CH2:21][Cl:20])[CH2:18][CH2:17][S:16]1

Participants

5

Reactant 3

HCID 241Benzene2×HCID 6577Chloroacetyl chlorideHCID 20221967HCID 20221967, compound

Product 1

HCID 13363481HCID 13363481, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Twenty-three and five tenths ml. of a benzene solution containing 5.9 g. of 2(2',6'-dichlorophenyl) thiazolidine was combined with 25 ml. of benzene and 2.8 g. of chloroacetyl chloride and the mixture stirred in an ice bath, while 2.6 g. of triethylamine was added dropwise. After standing for about 30 minutes the mixture was washed with water, separated, dried over magnesium sulfate and the benzene stripped off under vacuum. There was obtained a yield of 8 g. of an oil, the title compound, ND30 = 1.6041.

Workup

  1. washthe mixture was washed with water
  2. customseparated
  3. dry with materialdried over magnesium sulfate
  4. customThere was obtained a yield of 8 g

Sources & evidence

ORD record
ord-2ea9d73d697b45b797f5e3f3d9820436
Source dataset
uspto-grants-1978_02
Patent number
US04072688

Reaction notes

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