Benzene → HCID 12962346, compound

HRID 616025Notes

Reaction equation

HRID 616025 reaction equation
C1C=CC=CC=1.[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[NH:18][CH2:17][CH2:16][O:15]2)=[CH:10][CH:9]=1.[Cl:19][CH:20]([Cl:24])[C:21](Cl)=[O:22]>C(N(CC)CC)C>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([CH:14]2[N:18]([C:21](=[O:22])[CH:20]([Cl:24])[Cl:19])[CH2:17][CH2:16][O:15]2)=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 241Benzene2×HCID 6593Dichloroacetyl chlorideHCID 10058192Oxazolidine, 2-(4-chlorophenyl)-

Product 1

HCID 12962346HCID 12962346, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Twenty-two ml. of a benzene solution containing 5.5 g. of 2-p-chlorophenyl oxazolidine was mixed with 25 ml. of benzene and 3.1 g. of triethylamine and stirred at room temperature, while 4.4 g. of dichloroacetyl chloride was added dropwise. The mixture was allowed to stand for about 30 minutes, washed with water, separated, dried over magnesium sulfate and then stripped. There was obtained a yield of 8.4 g. of an oil, the title compound, ND30 = 1.5668.

Workup

  1. washwashed with water
  2. customseparated
  3. dry with materialdried over magnesium sulfate
  4. customThere was obtained a yield of 8.4 g

Sources & evidence

ORD record
ord-b491a8235bc64a9080428c81d98cdf81
Source dataset
uspto-grants-1978_02
Patent number
US04072688

Reaction notes

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