反应详情

温度

20 °C

2.5 g of silver oxide were added to a solution of 5 g of 3-(3',4'-dimethoxyphenyl)-piperidine in 25 ml of acetone and then 2.5 ml of isopropyl iodide were added dropwise. The mixture was stirred at 20° C for 24 hours and was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel. Elution with a 6-3-1 cyclohexane-chloroform-triethylamine mixture yielded 4.8 g of N-isopropyl-3-(3',4'-dimethoxyphenyl)-piperidine.

1. filtrationwas filtered
2. customThe filtrate was evaporated to dryness
3. customthe residue was chromatographed over silica gel
4. washElution with a 6-3-1 cyclohexane-chloroform-triethylamine mixture