反应详情

A solution of 4.8 g of N-isopropyl-3-(3',4'-dimethoxyphenyl)-piperidine in 48 ml of 66% hydrobromic acid was refluxed for an hour and was evaporated to dryness. The residue was crystallized from isopropanol and then acetone to obtain 4.2 g of N-isopropyl-3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide melting at 182° C.

1. customwas evaporated to dryness
2. customThe residue was crystallized from isopropanol