反应详情

1.07 G. of 1-amino-2-nitro-4-n-propylsulfinylbenzene and 1 g. of 5% palladized charcoal in 100 ml. methanol are treated with hydrogen at atmospheric pressure until the theoretical uptake of hydrogen has occured (about 1 hour). The mixture is filtered and the filtrate evaporated to give 1,2-diamino-4-n-propylsulfinylbenzene. This is treated, in 20 ml. acetone, with 2.5 g. methoxy carbonyl isothiocyanate. The mixture is kept at room temperature overnight and then concentrated under vacuum. The residue is triturated with ether and recrystallized from acetone, yielding 1,2-bis-(3-carbomethoxy-2-thioureido)-4-n-propylsulfinylbenzene.

1. custom(about 1 hour)
2. filtrationThe mixture is filtered
3. customthe filtrate evaporated