Methoxycarbonyl isothiocyanate → HCID 20371180, compound

HRID 616083Notes

Reaction equation

HRID 616083 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]#[N:10])=[CH:4][C:3]=1[NH2:11].[CH3:12][O:13][C:14]([N:16]=[C:17]=[S:18])=[O:15]>CC(C)=O>[CH3:12][O:13][C:14]([NH:16][C:17](=[S:18])[NH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]#[N:10])=[CH:4][C:3]=1[NH:11][C:17]([NH:16][C:14]([O:13][CH3:12])=[O:15])=[S:18])=[O:15]

Participants

4

Reactant 2

HCID 552246Methoxycarbonyl isothiocyanateHCID 132100373,4-Diaminophenyl thiocyanate

Product 1

HCID 20371180HCID 20371180, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2.6 G. 1,2-diamino-4-thiocyanatobenzene in 48 ml. acetone is treated overnight with 8 g. methoxy carbonyl isothiocyanate at room temperature. The solution is concentrated and the residue triturated with methanol and recrystallized from methanol-chloroform, yielding pure 1,2-bis-(3-methoxycarbonyl-2-thioureido)-4-thiocyanatobenzene.

Workup

  1. customat room temperature
  2. concentrationThe solution is concentrated
  3. customthe residue triturated with methanol
  4. customrecrystallized from methanol-chloroform

Sources & evidence

ORD record
ord-d5b46cca35f54f9e99cf6e1c885566f4
Source dataset
uspto-grants-1978_02
Patent number
US04072696

Reaction notes

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