HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-{4-[(Methoxymethyl)sulfanyl]-2-nitrophenyl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Chloromethyl Methyl Ether | HCID 7864 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Thiocyanic acid, 4-(acetylamino)-3-nitrophenyl ester | HCID 8180927 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-{4-[(Methoxymethyl)sulfanyl]-2-nitrophenyl}acetamide | HCID 20362834 | — |
Reaction Steps
2.37 G. of 1-acetamido-2-nitro-4-thiocyanatobenzene in 10 ml. dimethylformamide is treated, under nitrogen, with 0.38 g. sodium borohydride at 20°-30° C. After one hour at 20°-30° C., 1.6 ml. of chloromethyl methyl ether is added. The mixture is stirred for a further 3 hour period, then diluted with water. The crude product is filtered off and recrystallized from cyclohexane, yielding 1-acetamido-2-nitro-4-methoxymethylthiobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04072696 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-d6fb4c435f3a4444b619341409095e12 |
| Source note | uspto-grants-1978_02 |