Methoxycarbonyl isothiocyanate → HCID 20371203, compound

HRID 616112Notes

Reaction equation

HRID 616112 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[C:9]([S:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])[CH:8]=[CH:7][C:6]=1[NH2:19])(=[O:3])[CH3:2].[CH3:20][O:21][C:22]([N:24]=[C:25]=[S:26])=[O:23]>CC(C)=O>[C:1]([NH:4][C:5]1[CH:10]=[C:9]([S:11]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[O:12])[CH:8]=[CH:7][C:6]=1[NH:19][C:25]([NH:24][C:22]([O:21][CH3:20])=[O:23])=[S:26])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 552246Methoxycarbonyl isothiocyanateHCID 20371006HCID 20371006, compound

Product 1

HCID 20371203HCID 20371203, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

1 G. of 2-acetamido-1-amino4-phenylsulfinylbenzene in 30 ml. acetone is treated overnight with 2 g. methoxycarbonyl isothiocyanate. The solution is concentrated and the residue triturated with ether. Recrystallization yields 2-acetamido-1-(3-methoxycarbonyl-2-thioureido)-4-phenylsulfinylbenzene.

Workup

  1. concentrationThe solution is concentrated
  2. customthe residue triturated with ether
  3. customRecrystallization

Sources & evidence

ORD record
ord-8046cf01ebc141c589772ea1be80349e
Source dataset
uspto-grants-1978_02
Patent number
US04072696

Reaction notes

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