反应详情

1.5 G. of 4-carbamoylthio-1-(3-methoxycarbonyl-2-thioureido)-2-nitrobenzene is treated for four hours in a refluxing mixture of 160 ml. methanol and 40 ml. water and with 4 g. iron powder (added in two portions) and 1 g. ferrous sulfate. The mixture is filtered, and the filtrate concentrated. The residue is dissolved in chloroform and washed with water, then the solvent evaporated affording 2-amino-4-carbamoylthio-1-(3-methoxycarbonyl-2-thioureido)-benzene.

1. filtrationThe mixture is filtered
2. concentrationthe filtrate concentrated
3. dissolutionThe residue is dissolved in chloroform
4. washwashed with water
5. customthe solvent evaporated