Acetyl chloride → 2-Acetamido-4-carbamoylthio-1-(3-methoxycarbonyl-2-thioureido)benzene

HRID 616127Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[C:6]([S:8][C:9](=[O:11])[NH2:10])[CH:5]=[CH:4][C:3]=1[NH:12][C:13]([NH:15][C:16]([O:18][CH3:19])=[O:17])=[S:14].[C:20](Cl)(=[O:22])[CH3:21]>>[C:20]([NH:1][C:2]1[CH:7]=[C:6]([S:8][C:9](=[O:11])[NH2:10])[CH:5]=[CH:4][C:3]=1[NH:12][C:13]([NH:15][C:16]([O:18][CH3:19])=[O:17])=[S:14])(=[O:22])[CH3:21]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 203710642-Amino-4-carbamoylthio-1-(3-methoxycarbonyl-2-thioureido)benzene

Product 1

HCID 203712262-Acetamido-4-carbamoylthio-1-(3-methoxycarbonyl-2-thioureido)benzene

Procedure

0.7 G. of 2-amino-4-carbamoylthio-1-(3-methoxycarbonyl-2-thioureido)benzene is treated with 1.5 ml. of acetyl chloride. The mixture is stripped after two hours and the residue recrystallized to afford 2-acetamido-4-carbamoylthio-1-(3-methoxycarbonyl-2-thioureido)benzene.

Workup

customthe residue recrystallized

Sources & evidence

ORD record: ord-3f2cfe460997497d8fb91d84c732d43c
Source dataset: uspto-grants-1978_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04072696

Reaction notes

Loading…