Sodium borohydride → HCID 20371578, compound

HRID 616201Notes

Reaction equation

HRID 616201 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:27]=[CH:28][C:29]=1[O:30][CH3:31])[CH2:7][CH2:8][NH:9][CH:10](OCC1C=CC=CC=1)[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12].[BH4-].[Na+]>C(O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:27]=[CH:28][C:29]=1[O:30][CH3:31])[CH2:7][CH2:8][NH:9][CH2:10][CH:11]([OH:12])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=1[O:12][CH2:11][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 20371579HCID 20371579, compound

Product 1

HCID 20371578HCID 20371578, compoundYield 165.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3 g of α-(3,4-dimethoxyphenethylamino)-2-benzyloxyacetophenone hydrochloride, 0.7 g of sodium borohydride and 30 ml of ethanol are treated in the same manner as described in Example 1-(b). 2.5 g of α-(3,4-dimethoxyphenethylaminomethyl)-2-benzyloxybenzylalcohol hydrochloride are obtained. M.p. 115° - 117° C (recrystallized from a mixture of ethanol and ether).

Sources & evidence

ORD record
ord-d82c9b31f94648f4a92de5cea51c3ea1
Source dataset
uspto-grants-1978_02
Patent number
US04072759

Reaction notes

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