Bromine → HCID 20371691, compound

HRID 616215Notes

Reaction equation

HRID 616215 reaction equation
[BrH:1].[CH3:2][O:3][C:4]1[CH:27]=[CH:26][C:7]([C:8]([NH:10][C:11]2[CH:12]=[C:13]([CH:22]=[CH:23][C:24]=2[OH:25])[CH:14]([OH:21])[CH2:15][NH:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:9])=[CH:6][CH:5]=1.BrBr>C(O)(=O)C>[BrH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][C:11]2[CH:12]=[C:13]([CH:22]=[C:23]([Br:1])[C:24]=2[OH:25])[CH:14]([OH:21])[CH2:15][NH:16][C:17]([CH3:20])([CH3:18])[CH3:19])=[O:9])=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 20371686HCID 20371686, compound

Product 1

HCID 20371691HCID 20371691, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In substantially the same manner as described above in Example 35 3-(4-methoxybenzamido)-4-hydroxy-α-(tert.butylaminomethyl)benzylalcohol hydrobromide was brominated with bromine in glacial acetic acid. The analytically pure title compound was precipitated from the reaction mixture with ether. M.p. 168° - 169.6° C.

Workup

  1. customThe analytically pure title compound was precipitated from the reaction mixture with ether

Sources & evidence

ORD record
ord-452e851098aa4cedb9890be978af2f4f
Source dataset
uspto-grants-1978_02
Patent number
US04072760

Reaction notes

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