2-Chloroethyldiisopropylammonium chloride → 2-Propanamine, N-(2-(2-butoxyphenoxy)ethyl)-N-(1-methylethyl)-

Participants

Reaction Steps

To 750 ml of absolute ethanol was added gradually 13.8 g (0.60 mole) of metallic sodium cut into pieces. After all the sodium had reacted 49.8 g (0.30 mole) of o-butoxyphenol was added. The solution was cooled down in ice-water whereupon a solution of 60.0 g (0.30 mole) of diisopropylaminoethylchloride hydrochloride in 150 ml of absolute ethanol was added rapidly with stirring. The reaction mixture was then boiled under reflux for 5 hours.

Provenance & Evidence