反应详情

A mixture of 11 g of 5-amino-4-cyano-3-(ethylmethylamino)isothiazole, 6.8 g of methyl isocyanate, 2 ml of dibutyltin diacetate, and 50 ml of tetrahydrofuran was heated under reflux overnight. After cooling, the solution was evaporated under reduced pressure. The residue was recrystallized from toluene to yield 9.8 g of 1-methyl-3-(4-cyano-3-(ethylmethylamino)-5-isothiazolyl)urea, mp 175°. The ir and nmr spectra were consistent with the assigned structure.

1. temperaturewas heated
2. temperatureunder reflux overnight
3. temperatureAfter cooling
4. customthe solution was evaporated under reduced pressure
5. customThe residue was recrystallized from toluene