Hydrogen Peroxide → HCID 53990496, compound

HRID 616517Notes

Reaction equation

HRID 616517 reaction equation
[NH2:1][C:2]([N:9]([CH2:11][CH2:12][CH2:13][CH3:14])[CH3:10])=[C:3]([C:7]#[N:8])[C:4](=[S:6])[NH2:5].OO>C(O)C>[NH2:5][C:4]1[S:6][N:1]=[C:2]([N:9]([CH2:11][CH2:12][CH2:13][CH3:14])[CH3:10])[C:3]=1[C:7]#[N:8]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 85942051HCID 85942051, compound

Product 1

HCID 53990496HCID 53990496, compoundYield 74.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner of Example XI, part C, 61 g of 3-amino-3-(butylmethylamino)-2-cyanopropenethioamide in 200 ml of ethanol were treated with 33 ml of 30% hydrogen peroxide (9.8 g of active H2O2) to yield 45 g of 5-amino-3-(butylmethylamino)-4-cyanoisothiazole, mp 87°-89°. The ir and nmr spectra were consistent with the assigned structure.

Sources & evidence

ORD record
ord-940e951932474c5492cf5a8e85d1e977
Source dataset
uspto-grants-1978_02
Patent number
US04075001

Reaction notes

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