反应详情

196.3 g of 2,4,6-triethyl-2,6-dimethyl-1,2,5,6-tetrahydropyrimidine were added dropwise to 300 ml of concentrated hydrochloric acid at 30° - 40° C, with stirring. When all of the tetrahydropyrimidine had been added, the entire mixture was stirred for 4 - 5 hours and then neutralized with sodium carbonate and extracted with benzene. The resulting benzene solution was washed, in turn, with a 5% aqueous solution of sodium carbonate and with water, and was then dried over potassium carbonate. After removing the benzene, the residue was distilled under reduced pressure, giving 72.4 g of 5-amino-5-methyl-3-heptanone (bp 46° - 48° C/2.5 mmHg).

1. stirringthe entire mixture was stirred for 4 - 5 hours
2. extractionextracted with benzene
3. washThe resulting benzene solution was washed, in turn, with a 5% aqueous solution of sodium carbonate and with water
4. dry with materialwas then dried over potassium carbonate
5. customAfter removing the benzene
6. distillationthe residue was distilled under reduced pressure