Sodium sulfide nonahydrate → HCID 178508439, compound

HRID 616555Notes

Reaction equation

HRID 616555 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([Cl:9])=[N:4][C:3]=1Cl.O.O.O.O.O.O.O.O.O.[S-2:20].[Na+].[Na+]>CC(O)C>[NH2:1][C:2]1[C:3]([SH:20])=[N:4][C:5]([Cl:9])=[C:6]([Cl:8])[N:7]=1

Participants

4

Reactant 2

HCID 73972Sodium sulfide nonahydrateHCID 133411123,5,6-Trichloro-2-pyrazinamine

Product 1

HCID 178508439HCID 178508439, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 19.9 g. (0.1 mol.) of aminotrichloropyrazine, 25.2 g. (0.105 mol.) of sodium sulfide nonahydrate in 500 ml. of 2-propanol was heated to boiling under reflux for 5 hours. After cooling, the reaction mixture was filtered. The filtrate was neutralized with hydrochloric acid and filtered. The solid was washed with water and dried to give 11.4 g. (58% yield) of product.

Workup

  1. additionA mixture of 19.9 g
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling
  4. filtrationthe reaction mixture was filtered
  5. filtrationfiltered
  6. washThe solid was washed with water
  7. customdried
  8. customto give 11.4 g

Sources & evidence

ORD record
ord-8a67da4afc60420ba2ecec5cf52fa59c
Source dataset
uspto-grants-1978_02
Patent number
US04075207

Reaction notes

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