huagongshe.com
HRID616595

反应详情

EQUATION

反应方程式

HRID 616595 的结构方程式

REACTANTS

反应物

2
结构：COCCc1ccc(OCC2CO2)cc1
HCID92515

2,3-Epoxypropyl 4-(2-methoxyethyl)phenyl ether

C12H16O3

结构：O=C1NCCCN1C1CCNCC1
HCID15572666

1-(Piperidin-4-yl)tetrahydropyrimidin-2(1H)-one

C9H17N3O

PRODUCTS

生成物

1
结构：COCCc1ccc(OCC(O)CN2CCC(N3CCCNC3=O)CC2)cc1
HCID20368048

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 10.4 g of 1-[p-(2-methyoxyethyl)-phenoxy]-2,3-epoxy-propane and 9.15 g of 1-(4-piperidyl)-2-oxo-hexahydropyrimidine in 7 ml of abs. ethanol is heated for 5 hours to 95° C and then evaporated in vacuo. The residue is recrystallised from ethyl acetate/petroleum ether to yield the 1-[3-(p-(2-methoxyethyl)-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine, which melts at 113°-115° C.

WORKUP

后处理

  1. customevaporated in vacuo
  2. customThe residue is recrystallised from ethyl acetate/petroleum ether