HuagongsheHuagongshe Chemistry Print Report · For research reference only
((p-(2-Methoxyethyl)phenoxy)methyl)oxirane → 1-[3-(p-(2-Methoxyethyl)-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ((p-(2-Methoxyethyl)phenoxy)methyl)oxirane | HCID 92515 | — |
| Reactant | 1-(Piperidin-4-yl)-1,3-diazinan-2-one | HCID 15572666 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[3-(p-(2-Methoxyethyl)-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine | HCID 20368048 | — |
Reaction Steps
A solution of 10.4 g of 1-[p-(2-methyoxyethyl)-phenoxy]-2,3-epoxy-propane and 9.15 g of 1-(4-piperidyl)-2-oxo-hexahydropyrimidine in 7 ml of abs. ethanol is heated for 5 hours to 95° C and then evaporated in vacuo. The residue is recrystallised from ethyl acetate/petroleum ether to yield the 1-[3-(p-(2-methoxyethyl)-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine, which melts at 113°-115° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04075208 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-17f3cf3f7fa040d1859147e81cf70aea |
| Source note | uspto-grants-1978_02 |