Pyridinium chloride → HCID 54417079, compound

HRID 616633Notes

Reaction equation

HRID 616633 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][CH:27]=1)[C:6]([C:8]1[S:9][C:10]2[CH:22]=[C:21]([O:23]C)[CH:20]=[CH:19][C:11]=2[C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:7].Cl.N1C=CC=CC=1>C(OCC)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][CH:27]=1)[C:6]([C:8]1[S:9][C:10]2[CH:22]=[C:21]([OH:23])[CH:20]=[CH:19][C:11]=2[C:12]=1[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:7]

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 54272841HCID 54272841, compound

Product 1

HCID 54417079HCID 54417079, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Employing the procedure of Example 7, 5.0 g. (0.0134 mole) of the product from Example 11 was demethylated by treatment with 25 g. of pyridine hydrochloride for three hours in a 220° C. oil bath. Yellow crystals, obtained from ethyl acetate, were recrystallized from a mixture of 20 ml. of methanol and about 12 ml. of water to give 4.184 g. (91 percent) of the title compound as yellowish-brown crystals. Melting point 202.0°-202.5° C.

Workup

  1. customwere recrystallized from a mixture of 20 ml
  2. customof water to give 4.184 g

Sources & evidence

ORD record
ord-f805ab6a5a0a47ecbe4d489b8ff72c64
Source dataset
uspto-grants-1978_02
Patent number
US04075227

Reaction notes

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