Pyrazolam → HCID 12612439, compound

HRID 616662Notes

Reaction equation

HRID 616662 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH3:15])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[C:6]=2[CH:22]=1>CN(C)C=O.CN(CN(C)C)C.C(Cl)(=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][CH2:10][N:11]([CH3:12])[CH3:5])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[C:6]=2[CH:22]=1

Participants

5

Reactant 1

HCID 12562545Pyrazolam

Product 1

HCID 12612439HCID 12612439, compound

Reagents, catalysts & solvents 3

HCID 5829N,N,N',N'-TetramethylmethanediamineSolvent2×HCID 6228DimethylformamideSolventHCID 6367Acetyl chlorideSolvent

Procedure

In the manner given in Example 1, a solution of 8-bromo-1-methyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetramethyldiaminomethane and acetyl chloride (in 0.1 molar excess compared to the N,N,N',N'-tetramethyldiaminomethane), are reacted together to give 8-bromo-1-[2-(dimethylamino)ethyl]- 6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-843829b7b5854d2f8cf320df781ff463
Source dataset
uspto-grants-1978_02
Patent number
US04075221

Reaction notes

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