Acetyl chloride → HCID 20368145, compound

HRID 616665Notes

Reaction equation

HRID 616665 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH3:17])=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[C:8]=2[CH:24]=1)([O-:3])=[O:2].[C:25](Cl)(=O)[CH3:26]>CN(C)C=O>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][CH2:12][N:13]([CH2:14][CH2:25][CH3:26])[CH2:7][CH2:6][CH3:5])=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[C:8]=2[CH:24]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 20368157Pynazolam

Product 1

HCID 20368145HCID 20368145, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the manner given in Example 1, a solution of 8-nitro-1-methyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetrapropyldiaminomethane and acetyl chloride (in 0.1 molar excess compared to the N,N,N'N'-tetrapropyldiaminomethane) are reacted together to give 8-nitro-1-[2-(dipropylamino)ethyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-14239d3256884d67b0e1db84405b4fd8
Source dataset
uspto-grants-1978_02
Patent number
US04075221

Reaction notes

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