HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N,N',N'-Tetramethylmethanediamine → 8-methylthio-1-[2-(dimethylamino)ethyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N,N',N'-Tetramethylmethanediamine | HCID 5829 | — |
| Reactant | 8-methylthio-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20368149 | — |
| Solvent | Acetyl chloride | HCID 6367 | — |
| Product | 8-methylthio-1-[2-(dimethylamino)ethyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20368154 | — |
Reaction Steps
In the manner given in Example 1, a solution of 8-methylthio-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide N,N,N',N',-tetramethyldiaminomethane and acetyl chloride (in 0.1 molar excess compared to the N,N,N',N',-tetramethyldiaminomethane) are reacted together to give 8-methylthio-1-[2-(dimethylamino)ethyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04075221 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-6828e06e7e744a859612b6962e0b0edd |
| Source note | uspto-grants-1978_02 |