反应详情

A mixture of 0.5 g. (0.002 mole) of 2-phenyl-5,6-dihydro-s-triazolo[5,1-a]isoquinoline and 0.28 g. (0.002 mole) of N-bromoacetamide in 10 ml. of carbon tetrachloride is refluxed for 5 hours. The crystalline precipitate which forms is filtered and dissolved in methylene chloride. The resulting solution is washed with sodium bicarbonate, then the solvent is evaporated off and the obtained residue recrystallized from ethyl acetate. Yield 79%.

1. additionA mixture of 0.5 g
2. filtrationThe crystalline precipitate which forms is filtered
3. dissolutiondissolved in methylene chloride
4. washThe resulting solution is washed with sodium bicarbonate
5. customthe solvent is evaporated off
6. customthe obtained residue recrystallized from ethyl acetate