反应详情

A mixture of ethyl 5-chloroimidazo[1,2-a]quinoline-2-carboxylate 2.75 g. (0.01 mole) and 40 mg. of p-toluenesulfonic acid monohydrate in 150 ml. of n-butanol is heated at 100° C. for 18 hours. The butanol is then removed under reduced pressure. The residue is dissolved in a small amount of chloroform and chromatographed on a silica gel column. The fractions containing the title compound are combined and evaporated to dryness. The product can be further purified by crystallization.

1. customThe butanol is then removed under reduced pressure
2. dissolutionThe residue is dissolved in a small amount of chloroform
3. customchromatographed on a silica gel column
4. additionThe fractions containing the title compound
5. customevaporated to dryness
6. customThe product can be further purified by crystallization