Propargylamine → HCID 178456824, compound

Participants

Reaction Steps

A mixture of 2.9 g. of 1,6-dihydro-1,3-dimethyl7-(methylthio)-4-phenylpyrazolo[3,4-e][1,4]diazepine (prepared as disclosed in U.S. Pat. No. 3,770,762), 1.5 g. of 2-propynylamine and 50 ml. of ethanol is heated at reflux for 48 hours, then evaporated at reduced pressure to give a residue of 1,6-dihydro-1,3-dimethyl-4-phenyl-7-(2-propynylamino)pyrazolo[3,4-e][1,4]diazepine; m.p. 193°-195° C. after crystallization from ether.

Provenance & Evidence