Propargylamine → HCID 178456824, compound

HRID 616760Notes

Reaction equation

HRID 616760 reaction equation
[CH3:1][N:2]1[C:6]2[N:7]=[C:8](SC)[CH2:9][N:10]=[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:5]=2[C:4]([CH3:20])=[N:3]1.[CH2:21]([NH2:24])[C:22]#[CH:23]>C(O)C>[CH3:1][N:2]1[C:6]2[N:7]=[C:8]([NH:24][CH2:21][C:22]#[CH:23])[CH2:9][N:10]=[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:5]=2[C:4]([CH3:20])=[N:3]1

Participants

4

Reactant 2

HCID 239041PropargylamineHCID 20369034HCID 20369034, compound

Product 1

HCID 178456824HCID 178456824, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.9 g. of 1,6-dihydro-1,3-dimethyl7-(methylthio)-4-phenylpyrazolo[3,4-e][1,4]diazepine (prepared as disclosed in U.S. Pat. No. 3,770,762), 1.5 g. of 2-propynylamine and 50 ml. of ethanol is heated at reflux for 48 hours, then evaporated at reduced pressure to give a residue of 1,6-dihydro-1,3-dimethyl-4-phenyl-7-(2-propynylamino)pyrazolo[3,4-e][1,4]diazepine; m.p. 193°-195° C. after crystallization from ether.

Workup

  1. additionA mixture of 2.9 g
  2. temperatureat reflux for 48 hours
  3. customevaporated at reduced pressure

Sources & evidence

ORD record
ord-7baa9a764160483fa7f2fb46505ebdd7
Source dataset
uspto-grants-1978_02
Patent number
US04075408

Reaction notes

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