Propargylamine → HCID 178456823, compound

Participants

Reaction Steps

A mixture of 3.0 g. of 4-(2-fluorophenyl)-1,6-dihydro-1,3-dimethylpyrazolo[3,4-e][1,4]diazepine-7-thiol (prepared as disclosed in U.S. Pat. No. 3,770,762), 1.8 g. of 2-propynylamine and 50 ml. of tetrahydrofuran is heated at reflux for 2 hours, then evaporated at reduced pressure to give a residue of 4-(2-fluorophenyl)-1,6-dihydro-1,3-dimethyl7-(2-propynylamino)pyrazolo[3,4-e][1,4]diazepine; m.p. 202°-204° C. (dec.) after trituration with ether, filtration and drying.

Provenance & Evidence