Propargylamine → HCID 178456823, compound

HRID 616761Notes

Reaction equation

HRID 616761 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]2[C:18]([CH3:19])=[N:17][N:16]([CH3:20])[C:10]=2[N:11]=[C:12](S)[CH2:13][N:14]=1.[CH2:21]([NH2:24])[C:22]#[CH:23]>O1CCCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]2[C:18]([CH3:19])=[N:17][N:16]([CH3:20])[C:10]=2[N:11]=[C:12]([NH:24][CH2:21][C:22]#[CH:23])[CH2:13][N:14]=1

Participants

4

Reactant 2

HCID 239041PropargylamineHCID 178433927HCID 178433927, compound

Product 1

HCID 178456823HCID 178456823, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 3.0 g. of 4-(2-fluorophenyl)-1,6-dihydro-1,3-dimethylpyrazolo[3,4-e][1,4]diazepine-7-thiol (prepared as disclosed in U.S. Pat. No. 3,770,762), 1.8 g. of 2-propynylamine and 50 ml. of tetrahydrofuran is heated at reflux for 2 hours, then evaporated at reduced pressure to give a residue of 4-(2-fluorophenyl)-1,6-dihydro-1,3-dimethyl7-(2-propynylamino)pyrazolo[3,4-e][1,4]diazepine; m.p. 202°-204° C. (dec.) after trituration with ether, filtration and drying.

Workup

  1. additionA mixture of 3.0 g
  2. temperatureat reflux for 2 hours
  3. customevaporated at reduced pressure

Sources & evidence

ORD record
ord-99585647a79747609825c1db70aff212
Source dataset
uspto-grants-1978_02
Patent number
US04075408

Reaction notes

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