反应详情

温度

60 °C

A stirred solution of 90.0 g (0.686 mole) of 2-methylindole, 30.0 g (0.306 mole) of maleic anhydride, 350 ml of benzene and 5.0 ml of glacial acetic acid was heated at reflux under a nitrogen atmosphere for a period of approximately sixty-five hours. The resulting slurry was cooled to approximately 60° C and the solid was collected by filtration, washed with approximately 100 ml of benzene that had been heated to approximately 60° C. After drying to a constant weight of 29.7 g in vacuo at 60° C there was obtained 2,4-bis(2-methyl-3-indolyl)-4-oxobutanoic acid (Formula VII: R=Y=H; R1 =CH3) as a pale yellow solid which melted at 217°-218° C with decomposition.

1. temperatureat reflux under a nitrogen atmosphere for a period of approximately sixty-five hours
2. filtrationthe solid was collected by filtration
3. washwashed with approximately 100 ml of benzene that
4. temperaturehad been heated to approximately 60° C
5. customAfter drying to a constant weight of 29.7 g in vacuo at 60° C