N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy) quinazolin-2-yl)phenyl)butyramide hydrochloride → HCID 25012250, compound

HRID 61679Notes

Reaction equation

HRID 61679 reaction equation
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][O:25][CH3:26])[CH:20]=4)[N:15]=[C:14]([C:27]4[CH:28]=[C:29]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])[CH:30]=[CH:31][CH:32]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1>Cl>[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][O:25][CH3:26])[CH:20]=4)[N:15]=[C:14]([C:27]4[CH:28]=[C:29]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])[CH:30]=[CH:31][CH:32]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1

Participants

3

Reactant 1

HCID 66826667N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy) quinazolin-2-yl)phenyl)butyramide hydrochloride

Product 1

HCID 25012250HCID 25012250, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The purified solid was taken up in HCl (4M in 1,4 dioxane, 30 mL) and stirred at RT for 4.5 h. The volatiles were removed in vacuo and the residue was triturated with Et2O to give N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy) quinazolin-2-yl)phenyl) butyramide hydrochloride (0.091 g, 0.171 mmol, 55% over two steps). MS 497 (M+1). HPLC retention time 5.547 mins.

Workup

  1. customThe volatiles were removed in vacuo
  2. customthe residue was triturated with Et2O

Sources & evidence

ORD record
ord-5c1738750a6b44908352ee0b8d8e7855
Source dataset
uspto-grants-2016_09
Patent number
US09440961B2

Reaction notes

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