HRID61681

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCCC4=O)ccc3n2)c1.Cl

HCID66826083

未命名化合物

PRODUCTS

生成物

结构：CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCCC4=O)ccc3n2)c1

HCID25012253

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

PROCEDURE

实验过程

The purified solid was taken up in HCl (4M in 1,4 dioxane, 30 mL) and stirred at RT for 4 h. The volatiles were removed in vacuo and the residue was washed with CH2Cl2 to give N-(3-(4-(1H-indazol-5-ylamino)-6-(2-(2-oxopyrrolidin-1-yl)ethoxy)quinazolin-2-yl)phenyl)butyramide hydrochloride (0.025 g, 0.043 mmol, 23% over two steps). MS 550 (M+1). HPLC retention time 5.30 mins.

WORKUP

后处理

customThe volatiles were removed in vacuo
washthe residue was washed with CH2Cl2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9a93396c39cb4addac856bb2d8952c4c
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09440961B2
来源说明: uspto-grants-2016_09

反应 SMILES

Cl.[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][N:25]5[CH2:29][CH2:28][CH2:27][C:26]5=[O:30])[CH:20]=4)[N:15]=[C:14]([C:31]4[CH:32]=[C:33]([NH:37][C:38](=[O:42])[CH2:39][CH2:40][CH3:41])[CH:34]=[CH:35][CH:36]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1>Cl>[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][N:25]5[CH2:29][CH2:28][CH2:27][C:26]5=[O:30])[CH:20]=4)[N:15]=[C:14]([C:31]4[CH:32]=[C:33]([NH:37][C:38](=[O:42])[CH2:39][CH2:40][CH3:41])[CH:34]=[CH:35][CH:36]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1