反应详情

A mixture of 74 g (0.5 mole) of 2-hydroxy-benzopyrazine, 12 g of dimethylaniline and 250 ml of phosphorus oxychloride was heated under reflux for 10 minutes. At about 80° C, all the material had dissolved; the reaction solution was cooled and poured onto ice, and the product was filtered off. The residue was dried on clay and was then taken up in petroleum ether, and the solution was filtered through active charcoal. The reaction solution was evaporated and 78 g (87.5% of theory) of 2-chloro-benzopyrazine of melting point 48°-49° C, were obtained. ##STR33##

1. temperaturewas heated
2. temperatureunder reflux for 10 minutes
3. dissolutionAt about 80° C, all the material had dissolved
4. temperaturethe reaction solution was cooled
5. additionpoured onto ice
6. filtrationthe product was filtered off
7. customThe residue was dried on clay
8. filtrationthe solution was filtered through active charcoal
9. customThe reaction solution was evaporated