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Phenyl Isothiocyanate → 4-Hydroxy-6-N-phenylthiocarbamoyl-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenyl Isothiocyanate | HCID 7673 | — |
| 反応物 | 4,5,6,7-Tetrahydrothieno[2,3-c]pyridin-4-ol | HCID 12337023 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Hydroxy-6-N-phenylthiocarbamoyl-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridine | HCID 20366831 | 79% |
反応手順
To a solution of 4-hydroxy-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridine (5.8 g; 37.4 mmoles) in benzene (60 cc) and 95% ethanol (30 cc) is added dropwise a mixture of phenyl isothiocyanate (5.05 g; 37.4 mmoles) in benzene (20 cc). After stirring during 2.5 hours at room temperature, the resulting precipitate is filtered off, washed with ether and dried in vacuo (M.p. = 168° C; yield: 79%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04076819 |
| 出典データセット | uspto-grants-1978_02 |
| ORD ID | ord-3d69328eaf824cdc8b008681d392276f |
| 出典メモ | uspto-grants-1978_02 |